Claverie-Benureau S, Lebel B, Gaudin-Harding F
Reprod Nutr Dev (1980). 1981;21(4):591-600. doi: 10.1051/rnd:19810411.
Groups of rats were given either a control or a magnesium-deficient diet. The well-known allergy-like crisis, characterized by vasodilatation with redness of the ears and dermatosis, occurred spontaneously in the magnesium-deficient groups. The histamine (H) content and the distribution of the various white blood cells (WBC) were studied as a function of time. During the acute phase, there was a transitory elevation of total blood H and WBC, mainly affecting the polymorphonuclear (PMN) cells, eosinophils (EO) and basophils (BAS). The EO peak preceded that of H. The EO count was especially high during the first part of the acute phase, while H and BAS were higher during the second part of that phase. There were no BAS's in the blood of the controls and those in the Mg-deficient animals were only partly granulated. H, EO and mast cells (MC) were elevated in the spleen but not in the thymus during acute deficiency. The high H level in the spleen corresponded to the same high level in the blood. When the spleen suspensions were centrifuged, wide differences in supernatant and pellet histamine appeared, according to the deficiency period.
将大鼠分成几组，分别给予对照饮食或缺镁饮食。在缺镁组中，自发出现了以耳部血管扩张伴发红和皮肤病为特征的、众所周知的类似过敏的危象。研究了组胺（H）含量和各种白细胞（WBC）分布随时间的变化情况。在急性期，全血H和WBC出现短暂升高，主要影响多形核（PMN）细胞、嗜酸性粒细胞（EO）和嗜碱性粒细胞（BAS）。EO峰值先于H峰值出现。在急性期的第一阶段，EO计数特别高，而在该阶段的第二部分，H和BAS较高。对照组血液中没有BAS，缺镁动物血液中的BAS仅部分颗粒化。在急性缺乏期间，脾脏中的H、EO和肥大细胞（MC）升高，但胸腺中没有。脾脏中高水平的H与血液中的高水平相对应。当脾脏悬液离心时，根据缺乏期的不同，上清液和沉淀中的组胺出现了很大差异。
