Hosaka S, Yamada A, Tanzawa H, Momose T, Magatani H, Nakajima A
J Biomed Mater Res. 1980 Sep;14(5):557-66. doi: 10.1002/jbm.820140503.
The mechanical properties of the hydrogel membrane of poly(methyl methacrylate-N-vinylpyrrolidone) were studied for the purpose of making soft contact lenses for extended wear. The dependence of tensile fracture energy, flexibility, and recovery from deformation on the water content and thickness of the hydrogel membrane was studied. Reducing the thickness of a lens was found to exert a more advantageous effect than increasing its water content on maximizing the tensile fracture energy under the condition of an adequate supply of oxygen to the cornea through the contact lens. As long as its water content is controlled between 63 and 78%, the contact lens made of poly(methyl methacrylate-N-vinylpyrrolidone) has the flexibility on the same order as that of conventional soft contact lenses of poly(2-hydroxyethyl methacrylate). The rate of recovery from deformation increases with water content, and the residual elongation is negligible in the range of water content over about 70%. It is concluded that practical requirements for use of these contact lenses, determined by these three mechanical properties, can be satisfied at the same time if the water content of the contact lens is adjusted at about 70%.
为了制造可长期佩戴的软性隐形眼镜,对聚(甲基丙烯酸甲酯 - N - 乙烯基吡咯烷酮)水凝胶膜的机械性能进行了研究。研究了拉伸断裂能、柔韧性以及变形恢复与水凝胶膜含水量和厚度的关系。发现在通过隐形眼镜向角膜充分供氧的条件下,减小镜片厚度对最大化拉伸断裂能的效果比增加含水量更为有利。只要其含水量控制在63%至78%之间,由聚(甲基丙烯酸甲酯 - N - 乙烯基吡咯烷酮)制成的隐形眼镜具有与传统聚(甲基丙烯酸2 - 羟乙酯)软性隐形眼镜相同程度的柔韧性。变形恢复率随含水量增加而提高,在含水量超过约70%的范围内残余伸长可忽略不计。得出结论,如果将隐形眼镜的含水量调节至约70%,由这三种机械性能所决定的这些隐形眼镜使用的实际要求可同时得到满足。