Ravetto C, Santamaria L
Cancer Detect Prev. 1981;4(1-4):369-76.
In a study of 143 selected human stomachs, resected for different pathologic changes, specific criteria were adopted to define the features of early gastric cancer, carcinoma in situ, gastric dysplasia, and gastric maturation disorders. The results in general did not lead to agreement in diagnoses, except in cases of early carcinoma, intestinal metaplasia, adenomatous polyps, and maturation impairment. A theory concerning the morphogenesis of gastric cancer was proposed in accordance with the data presented. This theory takes into account all possibilities of differentiations and dedifferentiations of the gastric gland stem cell pathway, as was determined from data of experimental carcinogenesis.
在一项对143例因不同病理变化而切除的人胃的研究中，采用了特定标准来界定早期胃癌、原位癌、胃发育异常和胃成熟障碍的特征。总体而言，除早期癌、肠化生、腺瘤性息肉和成熟障碍病例外，诊断结果并未达成一致。根据所呈现的数据提出了一种关于胃癌形态发生的理论。该理论考虑了胃腺干细胞途径分化和去分化的所有可能性，这是从实验性致癌数据中确定的。
