Serov V V, Zolotarevskiĭ V B, Berestova A V
Arkh Patol. 1990;52(5):70-4.
Macroscopic, histologic and ultrastructural features of an early stomach carcinoma are presented on the basis of literature and the authors' data. Ultrastructural and immunohistochemical data confirm the concept of a common histogenesis of different histologic types of stomach carcinoma, i.e. from reserve cells. Carcinoma, most likely, develops from reserve cells of the foveolate epithelium and metaplastic epithelium of intestinal type (foci of incomplete intestinal metaplasia with sulfomucine secretion). The data are accumulating on the precancerous nature of severe epithelial dysplasia. The development of an early carcinoma from preexisting dysplasia was observed in patients after long follow-up with repeated gastric biopsies.
基于文献及作者的数据，介绍了早期胃癌的大体、组织学和超微结构特征。超微结构和免疫组化数据证实了不同组织学类型胃癌具有共同组织发生学的概念，即起源于储备细胞。癌很可能起源于胃小凹上皮和肠化生上皮（分泌硫酸黏液的不完全肠化生灶）的储备细胞。关于重度上皮异型增生的癌前性质的数据不断积累。经过长期随访并多次进行胃活检的患者中，观察到由先前存在的异型增生发展为早期癌的情况。
