Falor W H, Ward R M
Cancer Detect Prev. 1981;4(1-4):449-53.
In 65 patients with noninvasive or submucosal invasive well-differentiated carcinoma of the bladder observed for 15 months to 11 years, cytogenetic analysis by the direct technique (nonculture) has been serially performed. Markers (abnormal chromosomes) have been found in 45 tumors, and recurrence has developed in all 45, resulting in 16 deaths. Two of the 20 patients without markers have developed recurrence. In one recurrence, 8 months postdiagnosis, the karyotypic mode changed from 69 to 92, evidence of development of a new tumor in a bladder prone to neoplasia. Based on our overall cytogenetic experience with 200 patients with carcinoma of the bladder a new classification is presented. This classification, builds on objective cytogenetic characteristics of early carcinoma, including the presence or absence of marker chromosomes, allows accurate prognosis, and thus provides the basis for development of standard therapy.
对65例非浸润性或黏膜下浸润性高分化膀胱癌患者进行了为期15个月至11年的观察，并连续采用直接技术（非培养）进行细胞遗传学分析。在45个肿瘤中发现了标记物（异常染色体），所有这45例均出现复发，导致16例死亡。20例无标记物的患者中有2例出现复发。在1例复发患者中，诊断后8个月，核型模式从69变为92，这证明在易发生肿瘤的膀胱中出现了新肿瘤。基于我们对200例膀胱癌患者的总体细胞遗传学经验，提出了一种新的分类方法。这种分类方法基于早期癌的客观细胞遗传学特征，包括标记染色体的有无，能够进行准确的预后判断，从而为制定标准治疗方案提供依据。
