Falor W H, Ward R M
J Urol. 1978 Jan;119(1):44-8. doi: 10.1016/s0022-5347(17)57377-2.
In 53 cases of non-invasive or submucosal invasive well differentiated carcinoma of the bladder observed for 4 to 101 months cytogenetic analysis by the direct technique (non-culture) has been performed repeatedly. Markers, abnormal chromosomes, have been found in 33 patients and recurrence has developed in 32 of these 33 patients, resulting in 9 deaths. All but 1 of the 20 patients without markers have been observed for up to 8 years and have remained free of recurrence. In this 1 recurrence, 8 months post-diagnosis, the mode changed from 69 to 92, evidence of dedifferentiation and development of a new tumor in a bladder prone to neoplasia. Based on our over-all cytogenetic experience with 165 patients with carcinoma of the bladder a simplified classification is presented. This classification, built on measurable characteristics of early carcinoma, including the presence or absence of marker chromosomes, allows accurate prognostication and, thus, provides the foundation for development of standard therapy.
对53例非浸润性或黏膜下浸润性高分化膀胱癌患者进行了4至101个月的观察，并反复采用直接技术（非培养法）进行细胞遗传学分析。在33例患者中发现了标记物（异常染色体），这33例患者中有32例复发，导致9例死亡。20例无标记物的患者中，除1例之外，其余患者均已观察了8年，且未复发。在这例复发患者中，诊断后8个月，核型从69变为92，这是去分化以及在易发生肿瘤的膀胱中出现新肿瘤的证据。基于我们对165例膀胱癌患者的总体细胞遗传学经验，提出了一种简化分类法。这种分类法基于早期癌的可测量特征，包括标记染色体的有无，能够进行准确的预后判断，从而为制定标准治疗方案提供依据。
