Freeman M W, Spring-Mills E, Jones A L
J Gerontol. 1980 Jan;35(1):31-8. doi: 10.1093/geronj/35.1.31.
The retired breeder rat, an animal known to undergo premature aging and to develop hypercholesterolemia, was studied to determine the effect of oxandrolone, a synthetic hypolipidemic steroid, on serum lipoprotein subfractions. The methods utilized for this study included density ultracentrifugation, electron microscopic lipoprotein particle sizing, and disc gel electrophoresis. The data confirmed the cholesterol-lowering ability of oxandrolone and demonstrated that its effect on total serum cholesterol was limited to the low and high density lipoprotein subclasses. The drug-treated group had 50% less LDL cholesterol and 25% less HDL cholesterol. Though there was an absolute decrease in total serum cholesterol in both these fractions, there was a re-distribution of cholesterol, such that post-treatment LDL carried less cholesterol and HDL more cholesterol on a percentage basis than found in pre-treatment values. In the light of current concepts of atherogenicity these alterations are of interest and potentially of considerable value.
对已知会过早衰老并出现高胆固醇血症的退休种鼠进行了研究，以确定合成降血脂类固醇氧雄龙对血清脂蛋白亚组分的影响。本研究采用的方法包括密度超速离心、电子显微镜脂蛋白颗粒大小测定和圆盘凝胶电泳。数据证实了氧雄龙的降胆固醇能力，并表明其对总血清胆固醇的影响仅限于低密度和高密度脂蛋白亚类。药物治疗组的低密度脂蛋白胆固醇降低了50%，高密度脂蛋白胆固醇降低了25%。尽管这两个组分中的总血清胆固醇都有绝对下降，但胆固醇发生了重新分布，使得治疗后低密度脂蛋白携带的胆固醇百分比低于治疗前，而高密度脂蛋白携带的胆固醇百分比高于治疗前。根据目前关于动脉粥样硬化形成的概念，这些改变令人感兴趣，并且可能具有相当大的价值。
