癌症患者红细胞中精胺和亚精胺含量升高。
Elevated contents of spermidine and spermine in the erythrocytes of cancer patients.
作者信息
Uehara N, Shirakawa S, Uchino H, Saeki Y
出版信息
Cancer. 1980 Jan 1;45(1):108-11. doi: 10.1002/1097-0142(19800101)45:1<108::aid-cncr2820450120>3.0.co;2-w.
Red blood cells (RBC) from 69 patients with advanced cancer and 37 healthy controls were subjected to polyamine determination by using high-performance liquid chromatography. The polyamine contents in normal human RBC were spermidine 15.04 +/- 3.63 nmol and spermine 8.82 +/- 3.12 nmol per 10(10) RBC. Spermidine and spermine levels in RBC were elevated in patients with cancer (p less than 0.005). Serial studies in seven patients with cancer indicated that both polyamines in RBC were reduced after successful surgery. Our data indicate that the determination of polyamine levels in RBC is clinically useful as a marker of disease activity in patients with cancer.
采用高效液相色谱法对69例晚期癌症患者和37名健康对照者的红细胞（RBC）进行多胺测定。正常人每10¹⁰个红细胞中的多胺含量为亚精胺15.04±3.63 nmol、精胺8.82±3.12 nmol。癌症患者红细胞中亚精胺和精胺水平升高（p<0.005）。对7例癌症患者的系列研究表明，成功手术后红细胞中的两种多胺均降低。我们的数据表明，测定红细胞中的多胺水平在临床上可作为癌症患者疾病活动的标志物。
Zotero 插件