Lanes R, Lee P A, Plotnick L P, Kowarski A A, Migeon C J
Clin Pediatr (Phila). 1980 Jan;19(1):31-3. doi: 10.1177/000992288001900105.
Children between 2 and 4 standard deviations below the mean height for age with no specific cause to account for their short stature are usually considered to represent either constitutional delay of growth (CDG) or familial short stature (FSS). This study was undertaken to determine whether 167 patients who were referred to our clinic for short stature could be divided into two distinct populations that fit the criteria of CDG and FSS. When the patients were artificially divided into 2 subgroups based on skeletal age greater or less than 2 standard deviations below the mean, no significant difference in growth rates or midparental heights could be found between them. Height ages were significantly more delayed in the group with greater skeletal age delay. Midparental height of our total population of short children was less than the mean midparental height of normal American children. It was concluded that our patients did not distribute into these two clear-cut entities. Whether they represented one continuum or two largely overlapping populations could not be decided on the basis of our data.
年龄别身高低于均值2至4个标准差且无特殊原因导致身材矮小的儿童，通常被认为属于体质性生长发育延迟（CDG）或家族性矮小（FSS）。本研究旨在确定转诊至我院的167例身材矮小患者是否可分为符合CDG和FSS标准的两个不同群体。当根据骨龄是否低于均值2个标准差将患者人为分为两个亚组时，两组之间的生长速率或父母平均身高均无显著差异。骨龄延迟较大的组身高年龄延迟更为显著。我院身材矮小儿童的父母平均身高低于美国正常儿童的父母平均身高。得出的结论是，我们的患者并未分为这两个明确的类型。根据我们的数据，无法确定他们代表一个连续体还是两个大量重叠的群体。
