Hill R M, Carney L G
Invest Ophthalmol Vis Sci. 1980 Feb;19(2):207-10.
With the use of a closed-chamber microelectrode system, the buffering capacities of over 100 tear samples were measured in response to alkali challenge of several strengths. Although distinctive variations were found among the seven subjects studied, a substantially greater buffer capacity was consistently noted in all their tear responses to pH conditions of near 10 and above. These results are consistent with the early observations of Friedenwald, who demonstrated the buffering capacity of corneal tissue when challenged in this higher pH range, and may here be due to the onset of protein denaturation in the tears.
使用封闭腔微电极系统，针对几种强度的碱刺激，测量了100多个泪液样本的缓冲能力。尽管在所研究的7名受试者中发现了显著差异，但在他们所有泪液对接近10及以上pH值条件的反应中，始终观察到显著更高的缓冲能力。这些结果与弗里登瓦尔德早期的观察结果一致，他证明了角膜组织在这个较高pH范围内受到刺激时的缓冲能力，在这里可能是由于泪液中蛋白质变性的开始。
