Lawton W, O'Connor G, Nelson J, Fitz A
Invest Urol. 1980 Jan;17(4):320-3.
We studied urinary kallikrein excretion in the rat during unilateral release of 24-hr bilateral ureteral ligation (BUL). In six rats studied after 24 hr of BUL, the glomerular filtration rate was 20 per cent of that in the five sham-operated controls. In the BUL group, the urine flow rate was 5 fold greater, fractional sodium excretion 100 times greater, and fractional potassium excretion 5 times greater than in controls. Urinary kallikrein excretion in the BUL group was one-half that of the controls. However, urinary kallikrein excretion per functioning nephron was increased 3 fold in the BUL group. Five of six BUL rats with increased fractional sodium and water excretion also showed increased urinary kallikrein excretion/GFR when compared to controls. Our study suggests that after 24 hr of BUL in the rat, urinary kallikrein excretion is increased in relation to the remaining, functioning nephrons and suggests a role for the kallikrein-kinin system in the postobstructive salt and water losses.
我们研究了大鼠在单侧解除24小时双侧输尿管结扎（BUL）期间尿激肽释放酶的排泄情况。在接受24小时BUL的6只大鼠中，肾小球滤过率为5只假手术对照组大鼠的20%。在BUL组中，尿流率比对照组高5倍，钠排泄分数比对照组高100倍，钾排泄分数比对照组高5倍。BUL组的尿激肽释放酶排泄量是对照组的一半。然而，BUL组中每个有功能的肾单位的尿激肽释放酶排泄量增加了3倍。与对照组相比，6只BUL大鼠中有5只钠和水排泄分数增加，其尿激肽释放酶排泄量/肾小球滤过率也增加。我们的研究表明，大鼠在BUL 24小时后，相对于剩余的有功能的肾单位，尿激肽释放酶排泄量增加，提示激肽释放酶-激肽系统在梗阻后盐和水丢失中起作用。
