Sirinavin S, McCracken G H, Nelson J D
J Pediatr. 1980 Feb;96(2):331-4. doi: 10.1016/s0022-3476(80)80841-9.
Gentamicin half-life values based on pharmacologic calculations were determined in 23 infants and children with diminished renal function. The half-life times correlated significantly with serum creatinine concentrations in patients who had steady-state creatinine levels (Y = 0.379 + 3.841 X, R = 0.951, P less than 0.001). This relationship provides a basis for formulating gentamicin dosage in pediatric patients with renal failure. The half-life of gentamicin is estimated by multiplying the serum creatinine concentration by four; three-quarters of the loading dose is administered every two half-lives. When renal function is unstable and changing daily, gentamicin half-life cannot be reliably predicted from the serum creatinine value.
通过药理学计算确定了23例肾功能减退的婴幼儿和儿童的庆大霉素半衰期值。在肌酐水平处于稳态的患者中，半衰期与血清肌酐浓度显著相关（Y = 0.379 + 3.841X，R = 0.951，P＜0.001）。这种关系为制定肾衰竭儿科患者的庆大霉素剂量提供了依据。庆大霉素的半衰期可通过将血清肌酐浓度乘以4来估算；每两个半衰期给予四分之三的负荷剂量。当肾功能不稳定且每日变化时，无法从血清肌酐值可靠地预测庆大霉素半衰期。
