Yoshioka H, Takimoto M, Matsuda I, Hattori S
Arch Dis Child. 1978 Apr;53(4):334-7. doi: 10.1136/adc.53.4.334.
Gentamicin was given to paediatric patients with chronic renal disease complicated by infections by Gram-negative organisms, in which renal function varied from normal to severely insufficient. Peak serum levels after an intramuscular dose of 1 mg/kg body weight ranged from 3.1 to 9.4 microgram/ml, which appeared adequate for therapy. The peak value was not related to the renal function of the individual patients. The serum half-life of gentamicin correlated inversely with the value for endogenous creatinine clearance. A diagram for the estimation of the serum half-life of gentamicin using the creatinine clearance value is presented. As a practical guide, it is recommended that the dose of gentamicin in children with renal function impairment be 1 mg/kg given intramuscularly and that the interval between doses be almost three times as long as the serum half-life, which can be estimated by means of the diagram for individual patients. The accuracy and safety of this method were confirmed by treating children with this adjusted dosage schedule.
庆大霉素用于患有慢性肾病并伴有革兰氏阴性菌感染的儿科患者，这些患者的肾功能从正常到严重不全不等。肌肉注射1mg/kg体重后的血清峰值水平在3.1至9.4微克/毫升之间，这似乎足以用于治疗。峰值与个体患者的肾功能无关。庆大霉素的血清半衰期与内源性肌酐清除率值呈负相关。给出了一张使用肌酐清除率值估算庆大霉素血清半衰期的图表。作为实用指南，建议对肾功能受损儿童肌肉注射庆大霉素的剂量为1mg/kg，且给药间隔几乎是血清半衰期的三倍，血清半衰期可通过该图表为个体患者估算。通过按照这种调整后的给药方案治疗儿童，证实了该方法的准确性和安全性。
