Lucas C E, Bouwman D L, Ledgerwood A M, Higgins R
J Trauma. 1980 Jan;20(1):47-51.
The effects of supplemental albumin infusion on serum protein homeostasis were studied in 94 seriously injured patients who received an average of 14.4 transfusion, 9.2 L electrolyte solution, and 829 ml fresh frozen plasma before and during operation. Based on randomization, 46 patients received an average of 31 gm albumin during operation followed by 150 gm/day for 5 days; 48 patients received no albumin. Supplemental albumin caused a significant (p = less than 0.05) increase in total serum protein and albumin concentrations. In contrast, supplemental albumin caused a significant decrease in alpha 1 globulin, alpha 2 globulin, beta globulin, gamma globulin, and fibrinogen levels. The prothrombin time used as index of prothrombin concentration was significantly prolonged in albumin patients. These changes, not previously documented, need further evaluation to determine clinical significance.
在94例严重受伤患者中研究了补充白蛋白输注对血清蛋白稳态的影响，这些患者在手术前和手术期间平均接受了14.4次输血、9.2升电解质溶液和829毫升新鲜冰冻血浆。根据随机分组，46例患者在手术期间平均接受31克白蛋白，随后5天每天接受150克；48例患者未接受白蛋白。补充白蛋白导致血清总蛋白和白蛋白浓度显著升高（p<0.05）。相比之下，补充白蛋白导致α1球蛋白、α2球蛋白、β球蛋白、γ球蛋白和纤维蛋白原水平显著降低。在接受白蛋白治疗的患者中，用作凝血酶原浓度指标的凝血酶原时间显著延长。这些此前未记录的变化需要进一步评估以确定其临床意义。
