Heck E, Edgar M A, Hunt J L, Baxter C R
J Trauma. 1980 Jan;20(1):75-7.
Of the several tests which measure leukocyte bactericidal competency only one, chemotaxis, has been reported to reflect both leukocyte dysfunction and patient mortality in major thermal injury. To validate the reliability that chemotaxis reflects mortality functional chemotactic index (FCI) was measured in leukocytes from 33 patients with 30% or greater total body surface area burns. Additionally, nitroblue tetrazolium (NBT) reduction and O2 consumption were compared to FCI. Significant decreases were seen in FCI values compared to normals. No differences, however, were seen in FCI values between surviving and nonsurviving patients. NBT reduction and O2 consumption also showed decreases with a significant difference between the mean decrease in surviving and nonsurviving patients. While the data show all these laboratory tests to be reflective of significant impairments in host defense, they do not appear to be reliable as predictive indices of patient survival and therefore should not be interpreted as such.
在几种测量白细胞杀菌能力的测试中，据报道只有趋化性这一项测试能反映严重热损伤中白细胞功能障碍和患者死亡率。为了验证趋化性反映死亡率的可靠性，对33例烧伤总面积达30%或更高的患者白细胞中的功能性趋化指数（FCI）进行了测量。此外，还将硝基蓝四氮唑（NBT）还原试验和耗氧量与FCI进行了比较。与正常情况相比，FCI值显著降低。然而，存活患者和未存活患者的FCI值没有差异。NBT还原试验和耗氧量也显示出降低，存活患者和未存活患者的平均降低值之间存在显著差异。虽然数据表明所有这些实验室测试都能反映宿主防御功能的显著损害，但它们似乎不能作为患者生存的可靠预测指标，因此不应如此解读。
