Warden G D, Mason A D, Pruitt B A
J Clin Invest. 1974 Oct;54(4):1001-4. doi: 10.1172/JCI107815.
Leukocyte chemotaxis in vitro was studied by a modification of the Boyden technic in 46 thermally injured patients. All patients demonstrated a decrease in leukocyte migration through a Nuclepore filter toward a standard casein-serum chemotactic agent. Leukocyte chemotaxis was inversely correlated with burn size during the first 72 h after injury. After 72 h, leukocyte chemotaxis directly correlated with clinical status and was highly predictive for ultimate mortality. Since mortality was largely due to infection, these findings suggest that suppression of leukocyte chemotaxis may explain the susceptibility to opportunistic infection in thermally injured patients.
通过对博伊登技术进行改良，对46例热损伤患者的体外白细胞趋化性进行了研究。所有患者均表现出白细胞通过核孔滤膜向标准酪蛋白 - 血清趋化剂迁移的能力下降。在受伤后的头72小时内，白细胞趋化性与烧伤面积呈负相关。72小时后，白细胞趋化性与临床状态直接相关，并且对最终死亡率具有高度预测性。由于死亡率主要归因于感染，这些发现表明白细胞趋化性的抑制可能解释了热损伤患者易发生机会性感染的原因。
