热损伤患者体外白细胞趋化性的评估。
Evaluation of leukocyte chemotaxis in vitro in thermally injured patients.
作者信息
Warden G D, Mason A D, Pruitt B A
出版信息
J Clin Invest. 1974 Oct;54(4):1001-4. doi: 10.1172/JCI107815.
Abstract
Leukocyte chemotaxis in vitro was studied by a modification of the Boyden technic in 46 thermally injured patients. All patients demonstrated a decrease in leukocyte migration through a Nuclepore filter toward a standard casein-serum chemotactic agent. Leukocyte chemotaxis was inversely correlated with burn size during the first 72 h after injury. After 72 h, leukocyte chemotaxis directly correlated with clinical status and was highly predictive for ultimate mortality. Since mortality was largely due to infection, these findings suggest that suppression of leukocyte chemotaxis may explain the susceptibility to opportunistic infection in thermally injured patients.
摘要
通过对博伊登技术进行改良，对46例热损伤患者的体外白细胞趋化性进行了研究。所有患者均表现出白细胞通过核孔滤膜向标准酪蛋白 - 血清趋化剂迁移的能力下降。在受伤后的头72小时内，白细胞趋化性与烧伤面积呈负相关。72小时后，白细胞趋化性与临床状态直接相关，并且对最终死亡率具有高度预测性。由于死亡率主要归因于感染，这些发现表明白细胞趋化性的抑制可能解释了热损伤患者易发生机会性感染的原因。
相似文献
1
Evaluation of leukocyte chemotaxis in vitro in thermally injured patients.热损伤患者体外白细胞趋化性的评估。
J Clin Invest. 1974 Oct;54(4):1001-4. doi: 10.1172/JCI107815.
2
Clinical significance of leukocyte infiltrative response in deep wound of patients with major burns.大面积烧伤患者深部创面白细胞浸润反应的临床意义
Burns. 2006 Dec;32(8):946-50. doi: 10.1016/j.burns.2006.03.003. Epub 2006 Aug 8.
3
[Effect of Soluvit on stress reaction and leucocyte function in serious burn patients in shock stage].
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2007 May;19(5):287-9.
4
Fungal wound infection (not colonization) is independently associated with mortality in burn patients.真菌性伤口感染（而非定植）与烧伤患者的死亡率独立相关。
Ann Surg. 2007 Jun;245(6):978-85. doi: 10.1097/01.sla.0000256914.16754.80.
5
[Neutrophil chemotaxis and burn infection].
Zhonghua Wai Ke Za Zhi. 1983 Mar;21(3):134-7.
6
Incidence of systemic fungal infection and related mortality following severe burns.严重烧伤后系统性真菌感染的发病率及相关死亡率
Burns. 2008 Dec;34(8):1108-12. doi: 10.1016/j.burns.2008.04.007. Epub 2008 Aug 8.
7
Defective granulocyte chemotaxis in the Chediak-Higashi syndrome.切迪阿克-希加希综合征中粒细胞趋化性缺陷。
J Clin Invest. 1971 Dec;50(12):2645-52. doi: 10.1172/JCI106765.
8
A comparison of leukocyte function and burn mortality.白细胞功能与烧伤死亡率的比较。
J Trauma. 1980 Jan;20(1):75-7.
9
Prognostic significance of abnormal neutrophil chemotaxis after thermal injury.
J Trauma. 1982 Mar;22(3):199-204. doi: 10.1097/00005373-198203000-00005.
10
Depressed mononuclear leukocyte chemotaxis in thermally injured patients.
J Immunol. 1977 Jul;119(1):199-205.
引用本文的文献
1
The renaissance man of burn surgery: Basil A. Pruitt, Jr.烧伤外科的文艺复兴式人物：小巴西尔·A·普鲁伊特
J Trauma Acute Care Surg. 2017 Nov;83(5):765-773. doi: 10.1097/TA.0000000000001651.
2
Spontaneous neutrophil migration patterns during sepsis after major burns.严重烧伤后脓毒症期间中性粒细胞的自发迁移模式。
PLoS One. 2014 Dec 9;9(12):e114509. doi: 10.1371/journal.pone.0114509. eCollection 2014.
3
Burn injury reduces neutrophil directional migration speed in microfluidic devices.烧伤会降低微流控设备中中性粒细胞的定向迁移速度。
PLoS One. 2010 Jul 30;5(7):e11921. doi: 10.1371/journal.pone.0011921.
4
Levofloxacin pharmacokinetics and pharmacodynamics in patients with severe burn injury.左氧氟沙星在重度烧伤患者中的药代动力学和药效学
Antimicrob Agents Chemother. 2006 Jun;50(6):1937-45. doi: 10.1128/AAC.01466-05.
5
Norepinephrine modulates myelopoiesis after experimental thermal injury with sepsis.去甲肾上腺素在实验性热损伤合并脓毒症后调节骨髓生成。
Ann Surg. 2001 Feb;233(2):266-75. doi: 10.1097/00000658-200102000-00017.
6
Mechanisms of neutropenia involving myeloid maturation arrest in burn sepsis.烧伤脓毒症中涉及髓系成熟停滞的中性粒细胞减少机制。
Ann Surg. 1998 Jul;228(1):112-22. doi: 10.1097/00000658-199807000-00017.
7
Current treatment of severely burned patients.重度烧伤患者的当前治疗方法。
Ann Surg. 1996 Jan;223(1):14-25. doi: 10.1097/00000658-199601000-00004.
8
Serum-mediated inhibition of polymorphonuclear leukocyte function following burn injury.烧伤后血清介导的多形核白细胞功能抑制
Ann Surg. 1981 Nov;194(5):568-75. doi: 10.1097/00000658-198111000-00004.
9
Regulation of neutrophil migratory function in burn injury by complement activation products.补体激活产物对烧伤中中性粒细胞迁移功能的调节
Ann Surg. 1984 Dec;200(6):742-6. doi: 10.1097/00000658-198412000-00012.
本文引用的文献
1
The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes.抗体与抗原混合物对多形核白细胞的趋化作用。
J Exp Med. 1962 Mar 1;115(3):453-66. doi: 10.1084/jem.115.3.453.
2
Alterations of the immune response following severe thermal injury.严重热损伤后免疫反应的改变。
Arch Surg. 1966 Jul;93(1):75-83. doi: 10.1001/archsurg.1966.01330010077011.
3
Chemotoxis of mononuclear cells.单核细胞的化学毒性
J Exp Med. 1968 Nov 1;128(5):1201-21. doi: 10.1084/jem.128.5.1201.
4
A simplified method for the measurement of chemotaxis of polymorphonuclear leukocytes from human blood.一种用于测量人血中多形核白细胞趋化性的简化方法。
J Lab Clin Med. 1971 Mar;77(3):501-9.
5
Neutrophil dysfunction and sepsis in burn injury.烧伤中的中性粒细胞功能障碍与脓毒症
Surg Gynecol Obstet. 1970 Mar;130(3):431-8.
6
7
Leukocyte locomotion and chemotaxis. New methods for evaluation, and demonstration of a cell-derived chemotactic factor.白细胞移动与趋化性。评估及证明一种细胞源性趋化因子的新方法。
J Exp Med. 1973 Feb 1;137(2):387-410. doi: 10.1084/jem.137.2.387.
8
Bacterial factors chemotactic for polymorphonuclear leukocytes.对多形核白细胞具有趋化作用的细菌因子。
Am J Pathol. 1968 Apr;52(4):725-36.
Zotero 插件