McMichan J C, Michel L, Westbrook P R
JAMA. 1980 Feb 8;243(6):528-31.
A prospective study of the pulmonary complications occurring in 22 consecutive patients admitted to hospital within 24 hours after acute traumatic quadriplegia was compared with the findings of a retrospective survey of 22 comparable patients. Patients in the prospective group received therapy designed to prevent or reverse secretion retention. All patients in this group survived. In the retrospective group there were nine deaths; pulmonary complications and the need for tracheal intubation and mechanical ventilation were three times more frequent. Serial pulmonary function testing in the prospective group demonstrated a greater compromise of expiration than inspiration and progressive improvement in diaphragm function with time. It is concluded that vigorous pulmonary therapy in the prospective group was associated with increased survival, a decreased incidence of pulmonary complications, and a decreased need for ventilatory support.
对22例急性创伤性四肢瘫痪后24小时内入院的连续患者发生的肺部并发症进行了前瞻性研究,并与22例类似患者的回顾性调查结果进行了比较。前瞻性组的患者接受了旨在预防或逆转分泌物潴留的治疗。该组所有患者均存活。回顾性组有9例死亡;肺部并发症以及气管插管和机械通气的需求频率高出三倍。前瞻性组的系列肺功能测试表明,呼气功能比吸气功能受损更严重,且随着时间的推移膈肌功能逐渐改善。得出的结论是,前瞻性组积极的肺部治疗与生存率提高、肺部并发症发生率降低以及通气支持需求减少有关。