蛋白质跨膜分泌的机制。

The mechanism of protein secretion across membranes.

作者信息

Davis B D, Tai P C

出版信息

Nature. 1980 Jan 31;283(5746):433-8. doi: 10.1038/283433a0.

PMID:7352023

Abstract

Many secreted proteins are synthesised as a large precursor with an additional hydrophobic N-terminal signal sequence that is cleaved by a membrane-bound enzyme. The proteins are secreted as nascent chains. The work leading to the current models of protein secretion is reviewed and the value of bacterial systems in the study of protein transfer across membranes is stressed.

摘要

许多分泌蛋白最初是作为一种带有额外疏水N端信号序列的大前体合成的，该信号序列会被一种膜结合酶切割。这些蛋白质以新生链的形式分泌。本文回顾了导致当前蛋白质分泌模型的研究工作，并强调了细菌系统在蛋白质跨膜转运研究中的价值。