Wu C H, Mangan C E, Burtnett M M, Mikhail G
Obstet Gynecol. 1980 Feb;55(2):157-62.
Random blood samples were obtained from 114 women with history of diethylstilbestrol (DES) exposure in utero and were analyzed for follicle-stimulating hormone (FSH), luteinizing hormone (LH), estrone (E1), estradiol (E2), androstenedione (A), testosterone (T), and progesterone (P) by respective radioimmunoassays. Colposcopic examinations of the lower genital tract and biopsies of suspicious areas of vaginal mucosa were performed in every patient. The mean age of these patients was 21.6 +/- 0.3 years (mean +/- SE) and mean age of menarche was 12.6 +/- 1.0 years. The incidence of irregular menses was 16.7%. A positive colposcopic finding was observed in 73.7% of all patients, 69.5% of patients with regular menses, and 94.7% of patients with irregular menses. Histologically confirmed vaginal adenosis was found in 43% of all patients, 46.3% of patients with regular menses, and 42.1% of patients with irregular menses. No significant differences were observed between DES-exposed versus unexposed females with regular menses in all hormones except testosterone. An elevated testosterone level was noted in postovulatory and perimenstrual phases of DES-exposed females. Elevated testosterone was also observed in DES-exposed females with irregular menses. Cross-analysis of hormone levels among the patients with lower genital tract pathology failed to show any statistical differences.
从114名有子宫内己烯雌酚（DES）暴露史的女性中采集随机血样，通过各自的放射免疫分析法分析卵泡刺激素（FSH）、黄体生成素（LH）、雌酮（E1）、雌二醇（E2）、雄烯二酮（A）、睾酮（T）和孕酮（P）。对每位患者进行下生殖道的阴道镜检查以及阴道黏膜可疑区域的活检。这些患者的平均年龄为21.6±614名有子宫内己烯雌酚（DES）暴露史的女性中采集随机血样，通过各自的放射免疫分析法分析卵泡刺激素（FSH）、黄体生成素（LH）、雌酮（E1）、雌二醇（E2）、雄烯二酮（A）、睾酮（T）和孕酮（P）。对每位患者进行下生殖道的阴道镜检查以及阴道黏膜可疑区域的活检。这些患者的平均年龄为21.6±0.3岁（平均值±标准误），月经初潮的平均年龄为12.6±1.0岁。月经不规律的发生率为16.7%。在所有患者中，73.7%观察到阴道镜检查结果为阳性，月经规律的患者中这一比例为69.5%，月经不规律的患者中这一比例为94.7%。在所有患者中，43%经组织学确诊为阴道腺病，月经规律的患者中这一比例为46.3%，月经不规律的患者中这一比例为42.1%。在月经规律的DES暴露女性与未暴露女性之间，除睾酮外，所有激素均未观察到显著差异。在DES暴露女性的排卵后期和月经周期周围阶段，观察到睾酮水平升高。在月经不规律的DES暴露女性中也观察到睾酮升高。对有下生殖道病变的患者的激素水平进行交叉分析，未显示出任何统计学差异。6±0.3岁（平均值±标准误），月经初潮的平均年龄为12.6±1.0岁。月经不规律的发生率为16.7%。在所有患者中，73.7%观察到阴道镜检查结果为阳性，月经规律的患者中这一比例为69.5%月经不规律的患者中这一比例为94.7%。在所有患者中，43%经组织学确诊为阴道腺病，月经规律的患者中这一比例为46.3%，月经不规律的患者中这一比例为42.1%。在月经规律的DES暴露女性与未暴露女性之间，除睾酮外，所有激素均未观察到显著差异。在DES暴露女性的排卵后期和月经周期周围阶段，观察到睾酮水平升高。在月经不规律的DES暴露女性中也观察到睾酮升高。对有下生殖道病变的患者的激素水平进行交叉分析，未显示出任何统计学差异。
