Liggitt H D, DeMartini J C
Vet Pathol. 1980 Jan;17(1):73-83. doi: 10.1177/030098588001700108.
Epithelia from 18 Holstein-Fresian calves with experimentally induced malignant catarrhal fever and two calves with naturally occurring disease had severe destructive inflammatory epithelial lesions. Calves were necropsied at early, mid and late clinical stages. Multifocal, degenerative and necrotic epithelial lesions were associated with lymphoid cells. Ultrastructurally, numerous lymphocytes, lymphoblasts and macrophages were accumulated between epithelial cells and in lamina propria, vessels and perivascular tissues. Epithelial cells in such lesions had variably severe degenerative changes or were necrotic but there was no proliferative response. Lesions were widespread in all calves and affected oral, ocular, gastrointestinal, ductal, urinary tract, choroid plexus and other epithelial tissues. Calves killed in late clinical stages had more severe lesions than those killed early. The predominantly lymphocytic, invasive-destructive pattern seen in tissues of cattle with malignant catarrhal fever was similar to that seen in such conditions as contact hypersensitivity and graft versus host disease. Viral structures were not seen.
对18头经实验诱导患恶性卡他热的荷斯坦 - 弗里生犊牛以及2头自然发病的犊牛的上皮组织进行检查，发现有严重的破坏性炎症上皮病变。在临床早期、中期和晚期对犊牛进行尸检。多灶性、退行性和坏死性上皮病变与淋巴细胞有关。超微结构显示，大量淋巴细胞、淋巴母细胞和巨噬细胞在上皮细胞之间以及固有层、血管和血管周围组织中积聚。此类病变中的上皮细胞有不同程度的严重退行性变化或坏死，但无增殖反应。病变在所有犊牛中广泛存在，累及口腔、眼、胃肠道、导管、泌尿道、脉络丛和其他上皮组织。临床晚期处死的犊牛病变比早期处死的更严重。恶性卡他热患牛组织中所见的以淋巴细胞为主的侵袭性破坏模式与接触性超敏反应和移植物抗宿主病等情况中所见的相似。未见到病毒结构。
