Liggitt H D, DeMartini J C
Vet Pathol. 1980 Jan;17(1):58-72. doi: 10.1177/030098588001700107.
A histologic, ultrastructural and immunohistochemical study of the vasculitis in the rete mirabile of 18 calves with experimental and two calves with spontaneous malignant catarrhal fevel showed lesions similar to those reported in graft rejection and some other lymphocyte-associated vasculopathies. The calves were examined at early, mid and late stages of clinical disease. Vascular lesions in the carotid rete were representative of those in other tissues examined. The magnitude of the arterial wall mononuclear cell infiltrate and the degree of arterial wall necrosis and degeneration increased with progression of the clinical disease. The predominant site of mononuclear cell accumulation was the adventitia. There was less medial and intimal involvement. The mononuclear infiltrate was composed of lymphocytes and macrophages with neutrophils and plasma cells rarely present. Endothelial hyperplasia, fibrinoid change and thrombosis were uncommon. Many changes contrasted with those recognized in an active Arthus reaction where adventitial change was minimal and most inflammatory cells were neutrophils or plasma cells. IgG and C3 rarely were detected in vessel walls with fluorescent antibody techniques. Serum immunoglobulins as measured by radial immunodiffusion were not elevated. Viral structures were not seen in tissues examined ultrastructurally.
对18头患有实验性恶性卡他热的犊牛和2头患有自发性恶性卡他热的犊牛的奇网血管炎进行了组织学、超微结构和免疫组织化学研究，结果显示病变与移植排斥及其他一些淋巴细胞相关性血管病变中所报道的相似。在临床疾病的早期、中期和晚期对犊牛进行了检查。颈动脉奇网中的血管病变代表了所检查的其他组织中的病变。随着临床疾病的进展，动脉壁单核细胞浸润的程度以及动脉壁坏死和变性的程度增加。单核细胞积聚的主要部位是外膜。中膜和内膜受累较少。单核细胞浸润由淋巴细胞和巨噬细胞组成，很少有中性粒细胞和浆细胞。内皮增生、纤维蛋白样改变和血栓形成并不常见。许多变化与在活跃的阿瑟斯反应中所观察到的不同，在阿瑟斯反应中，外膜变化最小，大多数炎症细胞是中性粒细胞或浆细胞。用荧光抗体技术在血管壁中很少检测到IgG和C3。通过放射免疫扩散法测定的血清免疫球蛋白未升高。在超微结构检查的组织中未见到病毒结构。
