Nakajima Y, Ishikawa Y, Kadota K, Kodama M, Honma Y
Hokkaido Branch, National Institute of Animal Health, Sapporo, Japan.
J Vet Med Sci. 1994 Dec;56(6):1065-8. doi: 10.1292/jvms.56.1065.
Surface marker analysis of the vascular and epithelial lesions in cattle with sheep associated malignant catarrhal fever (MCF) were done by immunohistochemistry using 7 monoclonal antibodies. MHC class I and II antigens were expressed in the degenerated portion of the vascular walls in addition to infiltrated leukocytes. The major population of mononuclear cells in these lesions were phenotypically macrophages. The other cells had BoCD4 or BoCD8, but rarely gamma delta T cell markers. These results suggest involvement of MHC restriction and macrophages, in addition to autoaggressive cytotoxic T lymphocytes, in the development of MCF vascular lesion.
利用7种单克隆抗体，通过免疫组织化学方法对患有绵羊相关恶性卡他热（MCF）的牛的血管和上皮病变进行了表面标志物分析。除浸润的白细胞外，MHC I类和II类抗原在血管壁的退化部分也有表达。这些病变中主要的单核细胞群体在表型上为巨噬细胞。其他细胞具有牛CD4或牛CD8，但很少有γδT细胞标志物。这些结果表明，除自身攻击性细胞毒性T淋巴细胞外，MHC限制和巨噬细胞也参与了MCF血管病变的发展。
