Gibbs R S, Huff R W
Am J Obstet Gynecol. 1980 Jan 1;136(1):32-7. doi: 10.1016/0002-9378(80)90560-8.
Sixty women with endometritis following cesarean section were treated with cefamandole (12 gm/day) alone. Specimens for culture were obtained by endometrial lavage and from peripheral blood. Minimum inhibitory concentrations were performed on anaerobes and enterococci by an agar dilution technique. Anaerobic organisms were isolated in 55 of 60 (91.7%) endometrial specimens. Bacteremia was documented in 12 patients (20%). Of 387 isolates from uterine cultures, 20 (5%) were resistant or had MIC's greater than or equal to 32 micrograms/ml. Ten patients (17%) were judged clinical failures and responded to additional antibiotics. Of 19 patients with Bacteroides fragilis or related species isolates in the uterus, three (15%) were judged as failures. Cefamandole was well tolerated and appears to be useful in the initial treatment of endomyometritis.
60例剖宫产术后发生子宫内膜炎的妇女仅接受头孢孟多治疗（12克/天）。通过子宫内膜灌洗和外周血获取培养标本。采用琼脂稀释技术对厌氧菌和肠球菌进行最低抑菌浓度测定。60份子宫内膜标本中有55份（91.7%）分离出厌氧菌。12例患者（20%）有菌血症记录。在从子宫培养物中分离出的387株菌株中，20株（5%）耐药或最低抑菌浓度大于或等于32微克/毫升。10例患者（17%）被判定为临床治疗失败，需加用其他抗生素。在子宫中分离出脆弱拟杆菌或相关菌种的19例患者中，3例（15%）被判定为治疗失败。头孢孟多耐受性良好，似乎可用于子宫内膜炎的初始治疗。
