Mathias C G, Chappler R R, Maibach H I
Arch Dermatol. 1980 Jan;116(1):74-6.
Lip swelling developed following the use of a cinnamic aldehyde-containing mouthwash in a woman with allergic rhinitis and asthma. Open application of the mouthwash on the antecubital fossae of the patient and control subjects produced immediate erythematous or urticarial responses in all tested individuals. Subsequent investigation established cinnamic aldehyde as the responsible ingredient. The incidence of positive reactions was shown to depend on site of application, vehicle, concentration, and time of reading. Of several related cinnamates, only cinnamic acid produced easily detectable responses at similar concentrations.
一名患有过敏性鼻炎和哮喘的女性在使用含肉桂醛的漱口水后出现唇部肿胀。将漱口水涂于患者和对照受试者的肘前窝，所有受试个体均立即出现红斑或荨麻疹反应。随后的调查确定肉桂醛是致病成分。结果显示，阳性反应的发生率取决于涂抹部位、赋形剂、浓度和观察时间。在几种相关的肉桂酸盐中，只有肉桂酸在相似浓度下能产生易于检测到的反应。
