Menin R A, Malmud L S, Petersen R P, Maier W P, Fisher R S
Ann Surg. 1980 Jan;191(1):66-71. doi: 10.1097/00000658-198001000-00013.
Thirty-six (36) patients with symptomatic gastroesophageal reflux were studied. Symptoms of heartburn, regurgitation and dysphagia were scored as to their severity and compared to quantitative tests of gastroesophageal reflux. Patients were studied with the acid reflux test, fiberoptic endoscopy, esophageal mucosal biopsy with a pinch forceps, esophageal manometry and radioisotopic gastroesophageal scintigraphy. Symptoms were scored according to an arbitrary grading system as mild, moderate, or severe. There were significant correlations between symptoms scores and both the degree of endoscopic esophagitis and the gastroesophageal reflux indices as measured by the radioisotopic scintiscan, but not with the degree of histologic esophagitis or lower esophageal sphincter pressure. Review of the findings suggests the following profile for patients who might require antireflux surgery: severe symptoms, presence of endoscopic esophagitis; resting lower esophageal sphincter pressure below 10 mmHg; and gastroesophageal reflux index above 10%.
对36例有症状的胃食管反流患者进行了研究。对烧心、反流和吞咽困难症状的严重程度进行评分，并与胃食管反流的定量检测结果进行比较。对患者进行了酸反流试验、纤维内镜检查、用活检钳取食管黏膜活检、食管测压和放射性核素胃食管闪烁扫描。症状根据一个任意的分级系统分为轻度、中度或重度。症状评分与内镜下食管炎程度以及放射性核素闪烁扫描测量的胃食管反流指数之间存在显著相关性，但与组织学食管炎程度或食管下括约肌压力无关。对研究结果的回顾表明，可能需要抗反流手术的患者具有以下特征：症状严重、存在内镜下食管炎；静息时食管下括约肌压力低于10mmHg；胃食管反流指数高于10%。
