Bale R N, Van Stone W W, Kuldau J M, Engelsing T M, Elashoff R M, Zarcone V P
Arch Gen Psychiatry. 1980 Feb;37(2):179-93. doi: 10.1001/archpsyc.1980.01780150069008.
This study compares the efficacy of three residential therapeutic communities and an outpatient methadone maintenance program for 585 male veterans addicted to heroin. Subjects were randomly assigned to the treatment modalities. More than 93% of the subjects completed both six- and 12-month questionnaires. In this report, the treatment settings, characteristics of the sample, assignment protocol, and pattern of treatment entry and first-year follow-up results are outlined. The various clinical demands that affected the research protocol, the degree to which the randomization was compromised, and the implications for the analysis of outcome are discussed. One year after admission to the study, subjects who had been in a therapeutic community for longer than seven weeks or in methadone treatment were more likely to be employed or attending school, and less likely to be in jail, using heroin, or to have been convicted of a serious crime, than subjects who received no treatment at all beyond a short detoxification period. Those who spent less than seven weeks in a therapeutic community were doing no better than subjects in the no treatment group.
本研究比较了三个住院治疗社区和一个门诊美沙酮维持治疗项目对585名海洛因成瘾男性退伍军人的疗效。研究对象被随机分配至不同治疗方式。超过93%的研究对象完成了6个月和12个月的问卷调查。本报告概述了治疗环境、样本特征、分配方案以及治疗进入模式和第一年随访结果。讨论了影响研究方案的各种临床需求、随机化受到损害的程度以及对结果分析的影响。在进入研究一年后,与仅接受短期戒毒治疗而未接受其他治疗的研究对象相比,在治疗社区接受治疗超过7周或接受美沙酮治疗的研究对象更有可能就业或上学,且入狱、使用海洛因或被判犯有严重罪行的可能性更小。在治疗社区停留时间少于7周的研究对象的情况并不比未治疗组的研究对象更好。