心肌梗死中的血小板释放反应。
Platelet-release reaction in myocardial infarction.
作者信息
Heptinstall S, Mulley G P, Taylor P M, Mitchell J R
出版信息
Br Med J. 1980 Jan 12;280(6207):80-1. doi: 10.1136/bmj.280.6207.80.
A study was made of the platelet-release reaction in heparinised platelet-rich plasma taken from 26 patients, of whom 22 had sustained a definite and four a possible myocardial infarction, and from 54 age-matched controls. No significant differences in reaction were observed between the two groups. Signficant differences were seen, however, between eight patients who died within a year after infarction and the controls (P less than 0.01) and the remaining 18 patients who survived (P = 0.02). These differences were abolished when sodium citrate was included in the experimental procedure. Poor prognosis was thus related to an increased platelet-release reaction after infarction.
对26名患者的肝素化富血小板血浆中的血小板释放反应进行了研究，其中22名患者发生了明确的心肌梗死，4名可能发生了心肌梗死，另有54名年龄匹配的对照者。两组之间未观察到反应的显著差异。然而，梗死一年内死亡的8名患者与对照组之间（P<0.01）以及其余存活的18名患者之间（P = 0.02）存在显著差异。当实验过程中加入柠檬酸钠时，这些差异消失。因此，预后不良与梗死后血小板释放反应增加有关。
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