Hammond E J, Ramsay R E, Villarreal H J, Wilder B J
Epilepsia. 1980 Feb;21(1):3-14. doi: 10.1111/j.1528-1157.1980.tb04039.x.
Long term effects of the intracortical implantation of blood and blood products on the electrocorticogram were studied in cats and guinea pigs. Focal epileptiform paroxysmal discharges developed after implantation of whole blood, hemolyzed erythrocytes, methemoglobin, ferritin, ferrous chloride, ferric chloride, fibrinogen, hemin, and cottonoid. In each group recurrent paroxysmal discharges became more prominent and more frequent after several months, suggesting a physiological change caused by a breakdown product of blood. The lesions were characterized by varying degrees of cell loss, iron deposition and glial proliferation. It is thought that posttraumatic epilepsy, which is frequently accompanied by extravasation of blood into the brain, might share a similar physiopathogenesis.
在猫和豚鼠身上研究了血液及血液制品皮质内植入对皮质电图的长期影响。植入全血、溶血红细胞、高铁血红蛋白、铁蛋白、氯化亚铁、氯化铁、纤维蛋白原、氯高铁血红素和棉片后，出现了局灶性癫痫样阵发性放电。在每个组中，数月后反复出现的阵发性放电变得更加明显和频繁，提示这是由血液分解产物引起的生理变化。这些病变的特征是不同程度的细胞丢失、铁沉积和胶质细胞增生。据认为，创伤后癫痫常伴有血液渗入脑内，可能具有类似的发病机制。
