Kaplan W D, Whitmore W F, Gittes R F
Invest Radiol. 1980 Jan-Feb;15(1):34-8. doi: 10.1097/00004424-198001000-00006.
Clinically occult lymph node metastases are a frequent finding in patients with carcinoma of the prostate. At present, lymph node dissection is the only reliable method of detecting local nodal spread; we have investigated a nonsurgical technique for demonstrating nodes using intraprostatic injections of 99mTc-Sb2S3. 99mTc-Sb2S3 (1.0 mCi/0.1--0.2 ml) was injected into the prostate glands of nine male mongrel dogs. Scintillation camera images revealed from one to four lymph nodes in each animal with earliest nodal visualization at 1 hour. A study performed on a 64-year-old man with prostatic cancer allowed visualization of seven pelvic lymph nodes, all of which were found to be histologically normal. The simplicity of this technique suggests the potential for both pre- and intraoperative identification of the prostatic lymph nodes. Clinical trials presently underway will allow assessment of the sensitivity and specificity of this technique for the detection of nodal metastases.
临床上隐匿性淋巴结转移在前列腺癌患者中很常见。目前，淋巴结清扫是检测局部淋巴结转移的唯一可靠方法；我们研究了一种非手术技术，通过向前列腺内注射99mTc-Sb2S3来显示淋巴结。将99mTc-Sb2S3（1.0毫居里/0.1 - 0.2毫升）注入9只雄性杂种狗的前列腺。闪烁相机图像显示每只动物有1至4个淋巴结，最早在1小时可观察到淋巴结显影。对一名64岁前列腺癌男性患者进行的研究显示有7个盆腔淋巴结显影，所有这些淋巴结经组织学检查均为正常。该技术操作简单，提示其在前列腺淋巴结术前及术中识别方面具有潜力。目前正在进行的临床试验将评估该技术检测淋巴结转移的敏感性和特异性。
