类风湿关节炎患者血清组氨酸：抗风湿药物治疗引起的变化。
Serum histidine in rheumatoid arthritis: changes induced by antirheumatic drug therapy.
作者信息
Pickup M E, Dixon J S, Lowe J R, Wright V
出版信息
J Rheumatol. 1980 Jan-Feb;7(1):71-6.
PMID:7354471
Abstract
Serum free histidine levels were studied in 15 patients with rheumatoid arthritis treated with D-penicillamine and 15 patients treated with hydroxychloroquine for 6 months. Both drugs produced improvement in the majority of patients, measured in terms of changes in 5 clinical parameters and plasma viscosity. A significant increase in serum histidine was observed only with D-penicillamine. This action, not seen with other specific antirheumatoid drugs may reflect a specific action of the drug.
摘要
对15例接受青霉胺治疗的类风湿性关节炎患者和15例接受羟氯喹治疗6个月的患者的血清游离组氨酸水平进行了研究。以5项临床参数和血浆粘度的变化衡量，两种药物在大多数患者中都产生了改善效果。仅青霉胺使血清组氨酸显著升高。这种其他特异性抗类风湿药物未见的作用可能反映了该药物的特异性作用。
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