Oppenheim W L, Williamson D H, Smith R
J Trauma. 1980 Feb;20(2):135-40. doi: 10.1097/00005373-198002000-00006.
To investigate whether biochemical changes soon after injury could be used as a measure of its severity or to predict its outcome we have examined the relationships of an injury severity score, initial blood metabolite concentrations, and subsequent biochemical changes in 33 injured patients. At about 4 hours after injury severity was related directly to blood lactate, pyruvate, and alanine (p less than 0.01), and inversely to blood ketone body concentrations (p less than 0.05). In 19 patients the daily total nitrogen, histidine, and 3-methylhistidine excretion was measured for 7 days. Only total urinary nitrogen was related to injury severity; 3-methylhistidine was inversely related to initial ketone body concentration; and histidine excretion was related to initial lactate, pyruvate, and alanine concentration. It is concluded that certain early biochemical measurements are significantly related to the severity of injury, and thus may be of practical importance.
为了研究损伤后不久的生化变化是否可用于衡量损伤的严重程度或预测其预后，我们对33例受伤患者的损伤严重程度评分、初始血液代谢物浓度及随后的生化变化之间的关系进行了研究。在受伤后约4小时，损伤严重程度与血乳酸、丙酮酸和丙氨酸直接相关（p<0.01），与血酮体浓度呈负相关（p<0.05）。对19例患者连续7天测定每日总氮、组氨酸和3-甲基组氨酸的排泄量。只有尿总氮与损伤严重程度相关；3-甲基组氨酸与初始酮体浓度呈负相关；组氨酸排泄与初始乳酸、丙酮酸和丙氨酸浓度相关。结论是某些早期生化指标与损伤严重程度显著相关，因此可能具有实际意义。
