人体腹部手术后的脂质代谢产物与氮平衡

Lipid metabolites and nitrogen balance after abdominal surgery in man.

作者信息

Foster K J, Alberti K G, Binder C, Hinks L, Karran S, Orskov H, Smythe P, Talbot S, Turnell D

出版信息

Br J Surg. 1979 Apr;66(4):242-5. doi: 10.1002/bjs.1800660407.

Abstract

The relation of lipid metabolism to nitrogen balance was studied in patients having undergone abdominal surgery and was compared with control subjects who had fasted for a similar period. The patients had lower circulating concentrations of glycerol, non-esterified fatty acids and ketone bodies. There were inverse correlations between blood alanine and ketone body concentrations in both patients (r = -0.64, P less than 0.01) and controls (r = -0.58, P less than 0.01). Nitrogen excretion by patients (12.7 mmol/kg body weight/day +/- 1.4 s.e. mean) was greater than by controls (9.2 mmol kg(-1)d(-1) +/- 0.8, P less than 0.05), but a more marked difference was noted for urinary methyl histidine excretion of 5.1 +/- 0.5 mmumol kg(-1) d(-1) by patients and only 2.5 +/- 0.3 mumol kg(-1) d(-1) by controls (P less than 0.01), a disparity indicative of more active protein turnover after surgery.

摘要

对接受腹部手术的患者的脂质代谢与氮平衡之间的关系进行了研究，并与禁食了相似时间段的对照受试者进行了比较。患者的甘油、非酯化脂肪酸和酮体的循环浓度较低。患者组（r = -0.64，P < 0.01）和对照组（r = -0.58，P < 0.01）的血液丙氨酸和酮体浓度之间均呈负相关。患者的氮排泄量（12.7 mmol/kg体重/天±1.4标准误均值）高于对照组（9.2 mmol kg⁻¹d⁻¹±0.8，P < 0.05），但患者尿甲基组氨酸排泄量为5.1±0.5 μmol kg⁻¹ d⁻¹，而对照组仅为2.5±0.3 μmol kg⁻¹ d⁻¹，差异更为显著（P < 0.01），这种差异表明手术后蛋白质周转更为活跃。