Grigor'iants R A, Meĭtina R A, Gasilin V S
Kardiologiia. 1980 Jan;20(1):50-3.
Blood oxygen transport function was studied in 40 patients with ischemic heart disease and afflicted or intact cardiac coronary arteries (as demonstrated by angiography) and in 23 individuals of the control group. Analysis of indices characterizing oxygen transport in patients with ischemic heart disease revealed diminished affinity of hemoglobin for oxygen with a shift of the oxyhemoglobin dissociation curve to the right and downward. The shift of the oxyhemoglobin dissociation curve is due a decrease in blood pH and increase of the role of auxiliary factors, 2,3-diphosphoglycerate in patricular. The shifts in the curve were more marked in patients with poor physical load tolerance and affliction of the three main coronary arteries, which is an act of compensation aimed at improving oxygenation of the heart muscle.
对40例缺血性心脏病患者（其心脏冠状动脉造影显示为病变或完好）及23名对照组个体的血氧运输功能进行了研究。对缺血性心脏病患者血氧运输特征指标的分析显示，血红蛋白与氧的亲和力降低，氧合血红蛋白解离曲线向右下方移动。氧合血红蛋白解离曲线的移动是由于血液pH值降低以及辅助因子（尤其是2,3 - 二磷酸甘油酸）作用增强所致。在体力负荷耐受性差且三支主要冠状动脉均有病变的患者中，曲线的移动更为明显，这是一种旨在改善心肌氧合的代偿行为。
