Carpentier A, Chauvaud S, Fabiani J N, Deloche A, Relland J, Lessana A, D'Allaines C, Blondeau P, Piwnica A, Dubost C
J Thorac Cardiovasc Surg. 1980 Mar;79(3):338-48.
Between January, 1969, and January, 1978, 551 patients with mitral incompetence were treated by a system of reconstructive techniques. Mitral valve incompetence was classified into three types according to leaflet pliability; type I normal leaflet motion, 150 cases; type II, leaflet prolapse, 213 cases; and type III, restricted leaflet motion, 188 cases. Associated tricuspid valvular disease was present in 174 cases (31.5%) and was treated by prosthetic ring annuloplasty. The operative mortality rate was 4.2% (16/377) in the mitral group and 14% (25/174) in the mitral-tricuspid group. Follow-up data are available in 341 patients from 1 year to 10 years (average 4 1/2 years). The late mortality rate was 7% (24/341). Actuarial curves including hospital mortality rate show an 82% survival rate at 9 years in the mitral group and a 79% rate in the mitral-tricuspid group. Thirty-seven patients (11%) underwent reoperation mainly for residual (17) or recurrent (16) mitral incompetence. Thromboembolism occurred in 12 patients for an embolic rate of 0.6% per patient-year, even though 48% were not given anticoagulants. Acorrding to the New York Heart Association (N.Y.H.A.) classification, 76% (207/270) of the patients were in Class I, 19% (51/270) were in Class II, 4% (10/270) were in Class III, and 0.7% were in Class IV (2/270). Results of postoperative catheterization and angiocardiography are available in 52 patients. Comparison between the various groups shows that the best results were obtained in type II mitral incompetence, followed by type I and type III mitral incompetence. This experience demonstrates that predictable and stable long-term results have been achieved by techniques of valvular reconstruction with a low incidence of thromboembolism. Reproducibility of the techniques is a limiting factor which can be overcome by adequate training and progressive experience. Patient selection is based on the valvular disease rather than age, physical condition, or cause of valvular disease.
1969年1月至1978年1月期间,551例二尖瓣关闭不全患者接受了重建技术系统治疗。根据瓣叶柔韧性,二尖瓣关闭不全分为三种类型:I型,瓣叶运动正常,150例;II型,瓣叶脱垂,213例;III型,瓣叶运动受限,188例。174例(31.5%)伴有三尖瓣疾病,采用人工瓣环成形术治疗。二尖瓣组手术死亡率为4.2%(16/377),二尖瓣 - 三尖瓣组为14%(25/174)。341例患者有1至10年(平均4.5年)的随访数据。晚期死亡率为7%(24/341)。包含医院死亡率的精算曲线显示,二尖瓣组9年生存率为82%,二尖瓣 - 三尖瓣组为79%。37例患者(11%)接受了再次手术,主要是因为残余(17例)或复发性(16例)二尖瓣关闭不全。12例患者发生血栓栓塞,栓塞率为每年0.6%/患者,尽管48%的患者未接受抗凝治疗。根据纽约心脏协会(N.Y.H.A.)分类,76%(207/270)的患者为I级,19%(51/270)为II级,4%(10/270)为III级,0.7%(2/270)为IV级。52例患者有术后导管检查和心血管造影结果。各亚组之间的比较表明II型二尖瓣关闭不全效果最佳,其次是I型和III型二尖瓣关闭不全。该经验表明,瓣膜重建技术已取得可预测且稳定的长期效果,血栓栓塞发生率低。技术的可重复性是一个限制因素,可通过充分培训和积累经验来克服。患者选择基于瓣膜疾病,而非年龄、身体状况或瓣膜疾病病因。