Shimada M, Kitamura Y, Yokoyama M, Miyano Y, Maeyama K, Yamatodani A, Takahashi Y, Tatsuta M
Nature. 1980 Feb 14;283(5748):662-4. doi: 10.1038/283662a0.
Histamine has been implicated in the pathogenesis of gastroduodenal ulcers. Since mast cells contain a considerable amount of histamine as well as heparin and other biologically active substances, it seems reasonable to speculate that they are involved in this process. In fact, development of gastroduodenal ulcers was reported in dogs with mastocytoma, and an increase in mast-cell number was described in the vicinity of human gastroduodenal ulcers. Y.K. et al. have recently found that the number of mast cells in a unit length of the skin of W/Wv mutant mice is less than 1% of the value for the congeneic +/+ mice and that no mast cells are detected in the intestinal canal of W/Wv mice. Therefore, this mutant mouse was used to investigate the role of mast cells in the induction of gastroduodenal ulcers. As a preliminary experiment, we examined the stomach and duodenum of W/Wv mice without any treatments. Unexpectedly, we found the spontaneous development of perforating stomach ulcers in W/Wv mice, suggesting that mast cells do not necessarily have aggravating effects on the production of stomach ulcers.
组胺已被认为与胃十二指肠溃疡的发病机制有关。由于肥大细胞含有大量组胺以及肝素和其他生物活性物质，推测它们参与这一过程似乎是合理的。事实上，有报道称患有肥大细胞瘤的犬会发生胃十二指肠溃疡，并且在人类胃十二指肠溃疡附近观察到肥大细胞数量增加。Y.K.等人最近发现，W/Wv突变小鼠单位长度皮肤中的肥大细胞数量不到同基因+/+小鼠的1%，并且在W/Wv小鼠的肠道中未检测到肥大细胞。因此，本研究使用这种突变小鼠来探讨肥大细胞在胃十二指肠溃疡诱导中的作用。作为初步实验，我们检查了未经任何处理的W/Wv小鼠的胃和十二指肠。出乎意料的是，我们发现W/Wv小鼠出现了自发性穿孔性胃溃疡，这表明肥大细胞不一定对胃溃疡的产生有加重作用。
