Kitamura Y, Go S, Hatanaka K
Blood. 1978 Aug;52(2):447-52.
Production of tissue mast cells was evaluated in genetically anemic mice of W/Wv genotype and was found to be abnormal. In the skin of adult W/Wv mice the number of mast cells/cm was less than 1% of the number observed in the congeneic +/+ mice. No mast cells were detectable in other tissues of the W/Wv mice. After transplantation of bone marrow cells from +/+ mice the number of mast cells in the skin, stomach, caecum, and mesentery of the W/Wv mice increased to levels similar to those of the +/+ mice. These results show that the W/Wv mouse is a useful tool for the investigations concerning the physiologic roles and the origin of mast cells.
对W/Wv基因型的遗传性贫血小鼠的组织肥大细胞生成情况进行了评估，发现其异常。在成年W/Wv小鼠的皮肤中，每平方厘米肥大细胞的数量不到同基因+/+小鼠中观察到数量的1%。在W/Wv小鼠的其他组织中未检测到肥大细胞。将+/+小鼠的骨髓细胞移植后，W/Wv小鼠皮肤、胃、盲肠和肠系膜中的肥大细胞数量增加到与+/+小鼠相似的水平。这些结果表明，W/Wv小鼠是研究肥大细胞的生理作用和起源的有用工具。
