Cabal L A, Siassi B, Zanini B, Hodgman J E, Hon E E
Pediatrics. 1980 Jan;65(1):50-6.
Neonatal heart rate variability (NHRV) was studied in 92 preterm infants (birth weight, 750 to 2,500 gm; gestational age, 28 to 36 weeks). Each infant was monitored continuously during the first 6 hours and for one hour at 24, 48, and 168 hours of life. During each hour NHRV was quantified and related to the following parameters: sex, gestational age, postnatal age, heart rate, and the presence and severity of respiratory distress syndrome (RDS). NHRV in healthy preterm infants was inversely related to heart rate level and directly related to the infant's postnatal age. In healthy babies with gestations of 30 to 36 weeks there was no significant correlation between NHRV and gestation. Decrease in NHRV was significantly related to the severity of RDS, and the reappearance of NHRV in infants with RDS was associated with a good prognosis. Decreased NHRV significantly differentiated the infants with RDS who survived after the fifth hour of life. The data reveal that NHRV (1) should be corrected for heart rate level and postnatal age; (2) is decreased in RDS; and (3) can be used as an indicator of morbidity and mortality in preterm infants with RDS.
对92名早产儿（出生体重750至2500克；胎龄28至36周）进行了新生儿心率变异性（NHRV）研究。在出生后的前6小时以及出生后24、48和168小时各持续监测1小时。在每个小时内，对NHRV进行量化，并与以下参数相关联：性别、胎龄、出生后年龄、心率以及呼吸窘迫综合征（RDS）的存在和严重程度。健康早产儿的NHRV与心率水平呈负相关，与出生后年龄呈正相关。在胎龄为30至36周的健康婴儿中，NHRV与胎龄之间无显著相关性。NHRV降低与RDS的严重程度显著相关，RDS婴儿中NHRV的再次出现与良好预后相关。NHRV降低显著区分了出生后5小时后存活的RDS婴儿。数据表明，NHRV（1）应根据心率水平和出生后年龄进行校正；（2）在RDS中降低；（3）可作为RDS早产儿发病和死亡的指标。
