尼泊尔婴儿心率变异性与神经认知及社会情感发展之间的关联
The Association Between Heart Rate Variability and Neurocognitive and Socio-Emotional Development in Nepalese Infants.
作者信息
Ask Torvald F, Ranjitkar Suman, Ulak Manjeswori, Chandyo Ram K, Hysing Mari, Strand Tor A, Kvestad Ingrid, Shrestha Laxman, Andreassen Marita, Lugo Ricardo G, Shilpakar Jaya S, Shrestha Merina, Sütterlin Stefan
机构信息
Kavli Institute for Systems Neuroscience and Centre for Neural Computation, Norwegian University of Science and Technology, Trondheim, Norway.
Department of Research, Innlandet Hospital Trust, Lillehammer, Norway.
出版信息
Front Neurosci. 2019 Apr 26;13:411. doi: 10.3389/fnins.2019.00411. eCollection 2019.
BACKGROUND
Many young children in developing countries do not reach their developmental potential. Traditional methods for assessing developmental outcome are time consuming, thus, physiological measures that can contribute to the prediction of developmental outcomes in high risk groups have been suggested. Vagally mediated heart rate variability (vmHRV) is considered a neurophysiological or peripheral proxy for prefrontal and executive functioning and might serve as a supplement for traditional measurements of developmental status and as a potential useful risk indicator.
AIM
In the present study, we wanted to describe the vmHRV in Nepalese infants and relate it to the Bayley Scales of infant and toddler development, 3. edition (Bayley-III) subscales.
METHODS
600 Nepalese infants were included in the study. At 6-11 and 17-24 months, we measured neurodevelopmental and socio-emotional outcomes by the Bayley-III. Inter-beat intervals were recorded at two measurement points when the children were 17-24 months.
RESULTS
There was a high intraclass correlation between HRV indices generated from the two measurement points. No significant associations between vmHRV and Bayley-III sub scales were found at any time.
CONCLUSION
This study is the first to describe vmHRV in healthy infants and the relationship between Bayley-III scores. Our results suggest that vmHRV is not associated with measures of general development in infancy.
背景
发展中国家的许多幼儿未发挥出其发育潜力。传统的发育结果评估方法耗时较长，因此有人提出采用生理指标来预测高危人群的发育结果。迷走神经介导的心率变异性（vmHRV）被认为是前额叶和执行功能的神经生理或外周指标，可能作为传统发育状况测量的补充以及潜在的有用风险指标。
目的
在本研究中，我们想要描述尼泊尔婴儿的vmHRV，并将其与贝利婴幼儿发展量表第三版（Bayley-III）各分量表相关联。
方法
600名尼泊尔婴儿纳入本研究。在6 - 11个月和17 - 24个月时，我们用Bayley-III测量神经发育和社会情感结果。在儿童17 - 24个月时的两个测量点记录心跳间期。
结果
两个测量点得出的HRV指标之间存在较高的组内相关性。在任何时候均未发现vmHRV与Bayley-III各分量表之间存在显著关联。
结论
本研究首次描述了健康婴儿的vmHRV以及Bayley-III评分之间的关系。我们的结果表明，vmHRV与婴儿期的总体发育指标无关。
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