Chu K U, Higashide S, Evers B M, Ishizuka J, Townsend C M, Thompson J C
Department of Surgery, University of Texas Medical Branch, Galveston, USA.
Ann Surg. 1995 May;221(5):602-9; discussion 609-11. doi: 10.1097/00000658-199505000-00018.
The authors determined whether the trophic effects of bombesin (BBS) on the small bowel mucosa are mediated by either nonluminal factors or endogenous luminal secretion.
The gut hormone bombesin stimulates growth of small bowel mucosa. The mechanisms responsible for this trophic effect are not known.
Rats underwent construction of a Thiry-Vella fistula (TVF) of either the jejunum or ileum. On postoperative day 10, the two groups were subdivided to receive either saline (control) or bombesin (10 micrograms/kg, subcutaneously, three times a day). After 14 days, rats were killed and the TVF was removed. The mucosa was scraped and weighed, and DNA and protein content was determined.
Bombesin significantly increased mucosal weight and DNA and protein content of both the jejunal and ileal TVF compared with the control rats.
Bombesin-mediated stimulation of small bowel mucosal growth is mediated by factors that are independent of luminal contents and pancreaticobiliary secretion. Bombesin may prove to be an important enterotrophic factor for gut mucosal proliferation.
作者确定蛙皮素（BBS）对小肠黏膜的营养作用是否由非腔内因素或内源性腔内分泌介导。
肠道激素蛙皮素刺激小肠黏膜生长。这种营养作用的机制尚不清楚。
对大鼠行空肠或回肠的Thiry-Vella瘘管（TVF）构建。术后第10天，将两组再分为接受生理盐水（对照组）或蛙皮素（10微克/千克，皮下注射，每日3次）。14天后，处死大鼠并取出TVF。刮取黏膜并称重，测定DNA和蛋白质含量。
与对照大鼠相比，蛙皮素显著增加空肠和回肠TVF的黏膜重量以及DNA和蛋白质含量。
蛙皮素介导的小肠黏膜生长刺激是由独立于腔内内容物和胰胆分泌的因素介导的。蛙皮素可能被证明是肠道黏膜增殖的一种重要肠营养因子。
