Böcker W, Dralle H, Hüsselmann H, Bay V, Brassow M
Virchows Arch A Pathol Anat Histol. 1980;385(2):187-200. doi: 10.1007/BF00427404.
This immuno-histochemical description of thyroglobulin synthesis in human thyroid carcinomas is based on the analysis of 72 malignant thyroid neoplasms and about 100 cases of thyroid adenomas and other diseases of the thyroid gland. In our experience immuno-histochemistry has been an invaluable diagnostic adjunct to light microscopy for three reasons: 1) as an approach to a functional classification of thyroid carcinomas, 2) as an aid in the differential diagnosis of thyroid carcinomas of follicle cell type from tumors of other origins, 3) as an aid in the functional classification of non-cancerous thyroid tissue. In the field of metastasizing thyroid carcinoma this immuno-histochemical approach combined with a morphometrical method may enable accurate identification of patients for whom radioiodine therapy is appropriate.
本文对人类甲状腺癌中甲状腺球蛋白合成的免疫组化描述，基于对72例甲状腺恶性肿瘤以及约100例甲状腺腺瘤和其他甲状腺疾病的分析。根据我们的经验，免疫组化作为光镜检查的一种辅助诊断方法具有重要价值，原因有三点：1）作为甲状腺癌功能分类的一种方法；2）有助于鉴别滤泡细胞型甲状腺癌与其他来源的肿瘤；3）有助于对非癌性甲状腺组织进行功能分类。在转移性甲状腺癌领域，这种免疫组化方法与形态测量法相结合，可能有助于准确识别适合接受放射性碘治疗的患者。
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