[Investigations on the antimicrobial activity of amin-aldehyde-condensates. 5. Communication: azomethins of benzaldehyde (author's transl)].

In the scope of our research about the antimicrobial activity of amin-aldehyde-condensates a number of benzylidene-amines (azomethins of benzyldehyde) was synthesized by condensation of primary amines with benzaldehyde. Structures and physical constants are shown in table 1 and 2. The antimicrobial activity of these benzylidene-amines is demonstrated by the results of the disk-test (table 3), of the minimal inhibition concentration test (MIC, table 4) and the suspension test (table 5) following the method of the DGHM. The different hydrophilic behaviour was equalized by using the standard solution described earlier with 3% dioxane. The results show, that the germistatic activity of the benzylideneamines resembles or exceeds in some cases that of benzaldehyde (table 4). Some compounds show good fungistatic activity versus Trichophyton mentagrophytes (table 3). The bactericidal power versus Klebsiella pneumoniae, Pseudomonas aeruginosa and Proteus vulgaris is remarkable and quiet stronger than that of the benzaldehyde.