Manning F A, Platt L D, Sipos L
Am J Obstet Gynecol. 1980 Mar 15;136(6):787-95. doi: 10.1016/0002-9378(80)90457-3.
Five fetal biophysical variables, fetal breathing movements, fetal movements, fetal tone, qualitative amniotic fluid volume, and the nonstress test, were measured in the same observation period in 216 patients with high-risk pregnancies. All delivered within one week of the last observation. The relationship between individual biophysical variables and combinations of variables to the outcome of pregnancy as judged by five-minute Apgar score, fetal distress in labor, and perinatal mortality rate (PMN) was determined. For any single test, the false negative rate was low and was similar between tests, but the false positive rate was high (greater than 50%) and varied significantly between tests. Combining tests resulted in a significant change in both the false negative and false positive rates as compared to any single test. The most accurate differentiation of the normal from the compromised fetus was obtained when all five variables were studied. The PNM ranged from 0 when all variables were normal to 600 per 1,000 when all were abnormal. These data suggest that combined fetal biophysical testing is a more accurate method of antepartum fetal evaluation than any single method.
在216例高危妊娠患者的同一观察期内，测量了五项胎儿生物物理变量，即胎儿呼吸运动、胎动、胎儿肌张力、羊水容量定性以及无应激试验。所有患者均在最后一次观察后的一周内分娩。确定了个体生物物理变量以及变量组合与妊娠结局之间的关系，妊娠结局通过5分钟阿氏评分、产时胎儿窘迫和围产儿死亡率（PMN）来判断。对于任何一项单一检查，假阴性率较低且各检查之间相似，但假阳性率较高（大于50%）且各检查之间差异显著。与任何一项单一检查相比，联合检查导致假阴性率和假阳性率均有显著变化。当研究所有五项变量时，能最准确地区分正常胎儿和有问题的胎儿。围产儿死亡率在所有变量均正常时为0，在所有变量均异常时为每1000例中有600例。这些数据表明，与任何单一方法相比，联合胎儿生物物理检查是一种更准确的产前胎儿评估方法。
