Paul E
Arch Dermatol. 1980 Feb;116(2):182-5.
Series of "private" photographs taken of patients over many years can greatly aid in following the course of development of malignant melanomas. In one case of superficial spreading melanoma, the pigmented lesion displayed spread around the entire circumference, maintaining its round shape throughout its course. The other tumors enlarged by focused spreading at various points along the border, changing in shape over several years of development. The temporary appearacne of two closely adjacent pigmented lesions frequently occurred during the early development of malignant melanomas, followed by fusion after progressive spread. Lentigo maligna melanoma showed the greatest continuous alteration of shape. Different tumor types observed over similar periods of time showed different dynamics of growth with reference to shape (horizontal spreading growth) and depth to invasion (vertical growth).
多年来拍摄的一系列患者“私密”照片，对追踪恶性黑色素瘤的发展过程有很大帮助。在一例浅表扩散性黑色素瘤中，色素沉着病变呈圆周状扩散，在整个病程中保持圆形。其他肿瘤则通过沿边界不同点的集中扩散而增大，在数年的发展过程中形状发生变化。在恶性黑色素瘤的早期发展过程中，经常会出现两个紧密相邻的色素沉着病变，随后在渐进性扩散后融合。恶性雀斑样痣黑色素瘤的形状变化最为持续。在相似时间段内观察到的不同肿瘤类型，在形状（水平扩散生长）和侵袭深度（垂直生长）方面表现出不同的生长动态。
