Steele R W
Arch Dermatol. 1980 Feb;116(2):189-90.
This controlled double-blind study examined the efficacy of a single large inoculum of Staphylococcus aureus 502A in interrupting intrafamilial spread of recurrent staphylococcal abscesses. Forty families were enrolled in the study and 32 completed six months of follow-up care. All participants were first treated with oral oxacillin sodium or dicloxacillin sodium, twice daily hexachlorophene showers, and bacitracin given nasally for two weeks. Some then received nasal inoculation of 10(8) to 10(9) organisms of S aureus 502A while others were given only sterile broth. Fifteen of 17 families or 29 of 36 individuals who received 502A remained free of recurrence for six months of observation, while only four of 15 control families or 18 of 34 members had no recurrences (P less than .005). After six months after colonization, 83% of the treatment group retained the 502A organism.
这项对照双盲研究检验了金黄色葡萄球菌502A单次大剂量接种在阻断复发性葡萄球菌脓肿家庭内传播方面的疗效。40个家庭参与了该研究，32个家庭完成了6个月的随访护理。所有参与者首先接受口服苯唑西林钠或双氯西林钠治疗，每天两次用六氯酚沐浴，并鼻用杆菌肽两周。然后，一些人接受了10⁸至10⁹个金黄色葡萄球菌502A菌株的鼻内接种，而其他人只给予无菌肉汤。接受502A接种的17个家庭中的15个或36个人中的29个人在6个月的观察期内没有复发，而15个对照家庭中只有4个或34名成员中的18名没有复发（P<0.005）。定植6个月后，83%的治疗组保留了502A菌株。
