Spinks T J, Bewley D K, Paolillo M, Vlotides J, Joplin G F, Ranicar A S
J Nucl Med. 1980 Jan;21(1):41-6.
Turnover of sodium in the human hand was studied by neutron activation. Patients suffering from various metabolic abnormalities affecting the skeleton, who were undergoing routine neutron activation for the measurement of calcium, were investigated along with a group of healthy volunteers. Neutron activation labels the sodium atoms simultaneously and with equal probability regardless of the turnover time of individual body compartments. The loss of sodium can be described either by a sum of two exponentials or by a single power function. Distinctions between patients and normal subjects were not apparent from the exponential model but were brought out by the power function. The exponent of time in the latter is a measure of clearance rate. The mean values of this parameter in (a) a group of patients suffering from acromegaly: (b) a group including Paget's disease, osteoporosis, Cushing's disease, and hyperparathyroidism; and (c) a group of healthy subjects, were found to be significantly different from each other.
通过中子活化研究了人体手部钠的周转率。对患有影响骨骼的各种代谢异常且正在接受常规中子活化以测量钙的患者以及一组健康志愿者进行了调查。中子活化以相同概率同时标记钠原子，而不考虑各个身体腔室的周转时间。钠的流失可以用两个指数之和或单个幂函数来描述。从指数模型中，患者与正常受试者之间的差异并不明显，但幂函数揭示了这些差异。后者中时间的指数是清除率的一种度量。发现该参数在（a）一组肢端肥大症患者、（b）一组包括佩吉特病、骨质疏松症、库欣病和甲状旁腺功能亢进症的患者以及（c）一组健康受试者中的平均值彼此有显著差异。
