Neirinckx R D, Davis M A
J Nucl Med. 1980 Jan;21(1):81-3.
A potential Ge-68 leads to Ga-68 generator system, based on the adsorption of Ge-68 from a dilute hydrofluoric acid eluent onto a commercially available organic anionexchange resin, is described. The distribution coefficients between the resin and dilute hydrofluoric acid were measured for germanium and gallium, and the breakthrough of germanium from a generator column determined. Using 0.01 N HF, the Kd values are 27 and greater than 4,000 for gallium and germanium, respectively. Gallium-68 can be quantitatively collected with 4 ml of 0.01 N HF. After neutralization, this provides a biologically safe concentration of NaF for injection. The breakthrough levels of germanium-68 remain lower than 10(-4) for up to 600 collections.
描述了一种基于将稀氢氟酸洗脱液中的锗-68吸附到市售有机阴离子交换树脂上的潜在锗-68到镓-68发生器系统。测量了树脂与稀氢氟酸之间锗和镓的分配系数，并确定了发生器柱中锗的穿透情况。使用0.01N氢氟酸时，镓和锗的分配系数值分别为27和大于4000。可用4毫升0.01N氢氟酸定量收集镓-68。中和后，这提供了用于注射的生物安全浓度的氟化钠。在多达600次收集过程中，锗-68的穿透水平保持低于10^(-4)。
