在使用氧烯洛尔进行长期β-肾上腺素能受体阻滞期间原发性高血压患者的血浆去甲肾上腺素浓度
Plasma noradrenaline concentration in essential hypertension during long-term beta-adrenoceptor blockade with oxprenolol.
作者信息
Jones D H, Daniel J, Hamilton C A, Reid J L
出版信息
Br J Clin Pharmacol. 1980 Jan;9(1):27-31. doi: 10.1111/j.1365-2125.1980.tb04792.x.
Abstract
- Chronic beta-adrenoceptor blockade with oxprenolol causes elevation of plasma noradrenaline levels, as compared with placebo, despite a significant fall in blood pressure and pulse rate. 2. The plasma noradrenaline concentration is not influenced by the frequency of administration or the formulation of the drug. 3. Plasma noradrenaline levels are not correlated with the plasma concentration of the drug. 4. The changes in plasma noradrenaline concentrations support a peripheral rather than central mechanism of action of beta-adrenoceptor blockers in man.
摘要
- 与安慰剂相比，使用氧烯洛尔进行慢性β-肾上腺素能受体阻滞会导致血浆去甲肾上腺素水平升高，尽管血压和脉搏率显著下降。2. 血浆去甲肾上腺素浓度不受给药频率或药物剂型的影响。3. 血浆去甲肾上腺素水平与药物的血浆浓度无关。4. 血浆去甲肾上腺素浓度的变化支持β-肾上腺素能受体阻滞剂在人体中的作用机制是外周性而非中枢性的。
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