长期使用普萘洛尔、甲基多巴或苄氟噻嗪进行药物治疗的高血压患者的交感神经功能和肾素活性。

Sympathetic nervous function and renin activity in hypertensives on long term drug treatment with propranolol, methyldopa or bendrofluazide.

作者信息

Polak G, Reid J L, Hamilton C A, Jones D H, Dollery C T

出版信息

Clin Exp Hypertens (1978). 1978;1(1):1-9. doi: 10.3109/10641967809068591.

DOI:10.3109/10641967809068591

Abstract

Plasma noradrenaline and plasma renin activity were measured as indices of sympathetic activity and renin angiotensin system in similar groups of hypertensive patients receiving either propranolol, bendrofluazide or methyldopa. Plasma renin activity was similar in the propranolol and methyldopa groups and significantly lower (p less than 0.01) in both these groups than the diuretic treated subjects. Plasma noradrenaline was significantly lower (p less than 0.01) on methyldopa than either propranolol or bendrofluazide. These different effects on the renin angiotensin system and the sympathetic nervous system of these drugs may be relevant in the choice of long term therapy in hypertension.

摘要

在接受普萘洛尔、苄氟噻嗪或甲基多巴治疗的相似高血压患者组中，测定血浆去甲肾上腺素和血浆肾素活性，作为交感神经活动和肾素-血管紧张素系统的指标。普萘洛尔组和甲基多巴组的血浆肾素活性相似，且这两组的血浆肾素活性均显著低于（p<0.01）接受利尿剂治疗的受试者。甲基多巴治疗组的血浆去甲肾上腺素显著低于（p<0.01）普萘洛尔组或苄氟噻嗪组。这些药物对肾素-血管紧张素系统和交感神经系统的不同作用，可能与高血压长期治疗的药物选择有关。