酶诱导作用会增强丙吡胺的代谢并降低其疗效吗？
Enhanced metabolism and diminished efficacy of disopyramide by enzyme induction?
作者信息
Aitio M L, Vuorenmaa T
出版信息
Br J Clin Pharmacol. 1980 Feb;9(2):149-52. doi: 10.1111/j.1365-2125.1980.tb05825.x.
Abstract
1 Monitoring plasma levels of mono-N-dealkyldisopyramide (MND), the most important metabolite of disopyramide, has been considered unnecessary. 2 We measured plasma levels of both disopyramide and MND in 64 consecutive patients receiving long term oral therapy with disopyramide. 3 Six patients were found with high plasma levels of MND, and simultaneously low levels of disopyramide. 4 Three of these patients were taking simultaneously phenytoin. The other three had a relatively high dose of disopyramide with regard to their renal function. One patient had terminal uremia, three had less severe renal dysfunction. 5 The underlying mechanism and clinical significance of the findings are discussed.
摘要
- 监测双异丙吡胺最重要的代谢产物单-N-去烷基双异丙吡胺（MND）的血浆水平被认为没有必要。2. 我们对64例连续接受双异丙吡胺长期口服治疗的患者测定了双异丙吡胺和MND的血浆水平。3. 发现6例患者MND血浆水平高，同时双异丙吡胺水平低。4. 其中3例患者同时服用苯妥英。另外3例患者相对于其肾功能而言双异丙吡胺剂量较高。1例患者有终末期尿毒症，3例有不太严重的肾功能不全。5. 讨论了这些发现的潜在机制和临床意义。
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