Zaslavsky B Y, Borovskaya A A, Lavrinenko A K, Lisichkin A Y, Davidovich Y A, Rogozhin S V
Chem Phys Lipids. 1980 Jan;26(1):49-55. doi: 10.1016/0009-3084(80)90010-9.
The lytic action of several homologous series of surfactants including N-acyl derivatives of the Na-salt of amino acids on the egg lecithin multilamellar liposomes was examined. The affinity for the lipid membrane and the solubilising capacity of the agents were estimated. The contribution of a CH2 group and that of the polar head group of surfactants to the free energy of the agent's binding to the membrane were evaluated. The results obtained indicate that the contribution of a CH2 group to the free binding energy depends on the nature of the surfactants' head group. This dependence is attributed to either various localisation of the agent's molecules in the lipid bilayer or to different properties of the agent's hydrocarbon tails. The contributions of the head groups of the surfactants are assumed to reflect the affinity of these head groups for the lecithin polar head group at the membrane interface. The results obtained indicate some degree of specificity involved in the interactions of the head groups.
研究了包括氨基酸钠盐的N-酰基衍生物在内的几个同系物系列表面活性剂对卵磷脂多层层状脂质体的溶解作用。评估了这些试剂对脂质膜的亲和力和溶解能力。评估了表面活性剂的一个CH2基团和极性头基团对试剂与膜结合自由能的贡献。所得结果表明，一个CH2基团对自由结合能的贡献取决于表面活性剂头基团的性质。这种依赖性归因于试剂分子在脂质双层中的不同定位或试剂烃链的不同性质。表面活性剂头基团的贡献被认为反映了这些头基团对膜界面处卵磷脂极性头基团的亲和力。所得结果表明头基团相互作用存在一定程度的特异性。
